Fig. 1

The inhibitory gating variable, s and the inhibitory current, $I_{\mathrm{syn}}$. The dimensionless modified propofol model is simulated with inhibition modeled at $t=100$. Here ${\tau }_s=10$. a A time-trace of s. The dynamics of the gating variable s are decoupled from the rest of the system. The gating variable decays exponentially with decay constant ${\tau }_s$ where the value of this decay constant is linked to the amount of propofol present. b A time-trace of $I_{\mathrm{syn}}$. Recall the synaptic current is given by $I_{\mathrm{syn}}=g_{i}s(V-E_i)$. At the onset of dynamic behavior the synaptic current exhibits a rapid spike followed by an approximately exponential decay. Note the small kink at approximately $t=180$ due to the spike (action potential) in v