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Table 1 Stochastic synapse model and parameters. (S) for single-synapse model; (M) for memorymodel calculations, where different

From: Stabilization of Memory States by Stochastic Facilitating Synapses

(a) Presynaptic components

Synapse

Determinant of release probability, P rel (t)

Static

P rel (t)= p 0

Facilitating

P rel (t)= p 0 F(t), where between spikes: τ F d F d t =(1−F) and immediately following each spike: F + = F − + f F ( 1 p 0 − F − )

Depressing

P rel (t)= p 0 V, whereP(V = 1)=D(t);P(V = 0)=1 − D(t).Between spikes: τ D d D d t =(1−D) and immediately following successful release, D + =0, while immediately following unsuccessful release, D + = D −

(b) Postsynaptic components

Synapse

Determinant of synaptic gating variable,s(t)

All

Following successful release: s + = s − + α ˜ (1− s − )

Between successful releases: τ s d s d t =−s

(c) Parameters

Synapse

Presynaptic Ï„

p 0

Factors

Postsynaptic Ï„ s

α ˜

Static

–

0.5 (S)

–

100 ms

1 − exp(−0.25)

0.5 (M)

Facilitating

Ï„ F =500ms

0.1 (S)

f F =0.5 (S)

100 ms

1 − exp(−0.25)

0.25 (M)

f F =0.25 (M)

Depressing

Ï„ D =250ms

0.5

–

100 ms

1 − exp(−0.25)