Fig. 12

Illustration of the Hodgkin–Huxley sodium channel. This channel has eight states, where state 8 is the conducting state, and 20 reactions. The reactions are labeled in blue and are used to define the edge importance values $R_k$ in the figures below. The reaction rates ${\alpha }_m$, ${\alpha }_h$, ${\beta }_m$, and ${\beta }_h$ are voltage-dependent, defined in Eqs. 51–52