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Fig. 3 | The Journal of Mathematical Neuroscience

Fig. 3

From: A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model

Fig. 3

Neuron-astrocyte model with astrocyte feedback. P and \(P'\): main and secondary populations of pyramidal neurons. I: interneuron population. \(p(t)\): external input on population P. \({[\mathrm{Glu}]_{\mathrm{e}}}\) and \({[\mathrm{GABA}]_{\mathrm{e}}}\): glutamate and GABA extracellular concentrations. \({[\mathrm{Glu}]_{\mathrm{a}}}\) and \({[\mathrm{GABA}]_{\mathrm{a}}}\): glutamate and GABA astrocyte concentrations. Red arrows: \(P \rightarrow P\), \(P \rightarrow I\) and \(P \rightarrow P'\) couplings. Orange arrow: \(P' \rightarrow P\) coupling. Green arrow: \(I \rightarrow P\) coupling. Cyan arrows: glutamate and GABA release by populations P and I into extracellular space (fluxes \(J_{\gamma }^{en}\) and \(J_{\gamma}\)). Purple arrows: astrocyte and neural uptakes of neurotransmitters. Red dashed arrows: glutamate feedbacks on populations P and I. Brown dashed arrow: GABA feedback on population P

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