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Fig. 6 | The Journal of Mathematical Neuroscience

Fig. 6

From: A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model

Fig. 6

The dependency of the SNIC value on \(v_{2}\) explains the impact of an alteration of the GABA astrocytic uptake on the neural activity. Variation of \(p_{{\mathrm{SNIC}}}\) value according to \(v_{2}\) (left). Time series corresponding to LFP, \({[\mathrm{GABA}]_{\mathrm{e}}}\), \({[\mathrm{Glu}]_{\mathrm{e}}}\) and \(v_{2}=m_{\gamma} {\mathcal{S}}({[\mathrm{GABA}]_{\mathrm{e}}}, v_{\gamma }, r_{\gamma})\) (right from top to bottom) for \(p(t)\) a Gaussian variable. At \(t=40~\mbox{s}\), the GABA astrocytic uptake is artificially altered by setting \(V_{\gamma}^{{\mathrm{ae}}}=0\) for any subsequent time. The gray time window highlights the transient toward the new behavior

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