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Table 1 Model parameters and initial values

From: What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study

Initial and equilibrium values
\(c_{c}\) 50 nM (chosen)
\(c_{e}\) 250 μM (chosen)
\(c_{o}\) 1 mM (chosen)
\(b^{\mathrm{tot}}\) 40 μM [47]
Diffusion/reaction
\(D_{c}\) 220 \(\upmu \mathrm{m}^{2}\ \mathrm{s}^{-1}\) [48]
\(D_{b}\) 20 \(\upmu \mathrm{m}^{2}\ \mathrm{s}^{-1}\) [49]
\(\kappa _{b}^{-}\) 19 \(\mathrm{s}^{-1}\) [47]
\(\kappa _{b}^{+}\) 27 \(\upmu \mathrm{M}^{-1}\ \mathrm{s}^{-1}\) [47]
RyR channel
\(k_{a}^{-}\) 28.8 \(\mathrm{s}^{-1}\) [50]
\(k_{a}^{+}\) 1500 \(\upmu \mathrm{M}^{-4}\ \mathrm{s}^{-1}\) [50]
\(k_{b}^{-}\) 385.9 \(\mathrm{s}^{-1}\) [50]
\(k_{b}^{+}\) 1500 \(\upmu \mathrm{M}^{-3}\ \mathrm{s}^{-1}\) [50]
\(k_{c}^{-}\) 0.1 \(\mathrm{s}^{-1}\) [50]
\(k_{c}^{+}\) 1.75 \(\mathrm{s}^{-1}\) [50]
\(I_{R}^{\mathrm{ref}}\) \(3.5 \times 10^{-18}\ \mathrm{mol}\ \mathrm{s}^{-1}\) [51] (approx.)
SERCA pumps
\(I_{S}\) \(6.5 \times 10^{-21}\ \mathrm{mol}\ \upmu \mathrm{M}\ \mathrm{s}^{-1}\) [52], (adapt.)
\(K_{S}\) 180 nM [24]
PMCA pumps
\(I_{P}\) \(1.7\times 10^{-23}\ \mathrm{mol}\ \mathrm{s}^{-1}\) [53]
\(K_{P}\) 60 nM [54]
\(\rho _{P}\) 500 \(\upmu \mathrm{m}^{-2}\) (estim.)
NCX pumps
\(I_{N}\) \(2.5 \times 10^{-21}\ \mathrm{mol}\ \mathrm{s}^{-1}\) [53], (adapt.)
\(K_{N}\) 1.8 μM [53]
\(\rho _{N}\) 15 \(\upmu \mathrm{m}^{-2}\) (estim.)
Leakage
\(v_{l,e}\) 38 nm \(\mathrm{s}^{-1}\) (calc.)
\(v_{l,p}\) 4.5 nm \(\mathrm{s}^{-1}\) (calc.)