Table 1 Model parameters and initial values
From: What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study
Initial and equilibrium values | ||
\(c_{c}\) | 50Â nM | (chosen) |
\(c_{e}\) | 250 μM | (chosen) |
\(c_{o}\) | 1Â mM | (chosen) |
\(b^{\mathrm{tot}}\) | 40 μM | [47] |
Diffusion/reaction | ||
\(D_{c}\) | 220Â \(\upmu \mathrm{m}^{2}\ \mathrm{s}^{-1}\) | [48] |
\(D_{b}\) | 20Â \(\upmu \mathrm{m}^{2}\ \mathrm{s}^{-1}\) | [49] |
\(\kappa _{b}^{-}\) | 19 \(\mathrm{s}^{-1}\) | [47] |
\(\kappa _{b}^{+}\) | 27Â \(\upmu \mathrm{M}^{-1}\ \mathrm{s}^{-1}\) | [47] |
RyR channel | ||
\(k_{a}^{-}\) | 28.8 \(\mathrm{s}^{-1}\) | [50] |
\(k_{a}^{+}\) | 1500Â \(\upmu \mathrm{M}^{-4}\ \mathrm{s}^{-1}\) | [50] |
\(k_{b}^{-}\) | 385.9 \(\mathrm{s}^{-1}\) | [50] |
\(k_{b}^{+}\) | 1500Â \(\upmu \mathrm{M}^{-3}\ \mathrm{s}^{-1}\) | [50] |
\(k_{c}^{-}\) | 0.1 \(\mathrm{s}^{-1}\) | [50] |
\(k_{c}^{+}\) | 1.75 \(\mathrm{s}^{-1}\) | [50] |
\(I_{R}^{\mathrm{ref}}\) | \(3.5 \times 10^{-18}\ \mathrm{mol}\ \mathrm{s}^{-1}\) | [51] (approx.) |
SERCA pumps | ||
\(I_{S}\) | \(6.5 \times 10^{-21}\ \mathrm{mol}\ \upmu \mathrm{M}\ \mathrm{s}^{-1}\) | [52], (adapt.) |
\(K_{S}\) | 180Â nM | [24] |
PMCA pumps | ||
\(I_{P}\) | \(1.7\times 10^{-23}\ \mathrm{mol}\ \mathrm{s}^{-1}\) | [53] |
\(K_{P}\) | 60Â nM | [54] |
\(\rho _{P}\) | 500Â \(\upmu \mathrm{m}^{-2}\) | (estim.) |
NCX pumps | ||
\(I_{N}\) | \(2.5 \times 10^{-21}\ \mathrm{mol}\ \mathrm{s}^{-1}\) | [53], (adapt.) |
\(K_{N}\) | 1.8 μM | [53] |
\(\rho _{N}\) | 15Â \(\upmu \mathrm{m}^{-2}\) | (estim.) |
Leakage | ||
\(v_{l,e}\) | 38Â nm \(\mathrm{s}^{-1}\) | (calc.) |
\(v_{l,p}\) | 4.5Â nm \(\mathrm{s}^{-1}\) | (calc.) |