Figure 4

Effect of demyelination on propagation across a single internode. (a) Effect of demyelination on the probability of transmission \(p_{T}\) for the three cases shown in Fig. 1 (purple is orthodromic damage, blue is antidromic damage and red is damage on both sides of the node). A purple line is hidden behind the red curve, but stays at \(p_{T}=1\) over the range of damage intensities studied. (b) Effect of demyelination on transmission delay. Having negative delays means a propagation delay shorter than in the absence of damage. Delays corresponding to \(p_{T}<0.1\) are not plotted. (c) Same as (b) but for transmission jitter. (d) Spike timing distributions corresponding to 80% damage (based on a time discretization of 0.01 ms)