Figure 7

Homeostatic adjustment of threshold partially compensates for demyelination-induced delays and transmission probability across a single internode. For each demyelination intensity and depending on the antidromic-orthodromic location of the damage, we attempted to recover undamaged delays by adjusting the spiking threshold. (a) For 40% damage, the membrane potentials reaching the next node of Ranvier (full lines) are shown with their corresponding firing thresholds that minimize delay changes (dashed horizontal lines). (b) Delay probability distributions for the membrane potentials shown in (a). (c) The residual delay and (d) spike timing jitter are shown as a function of damage intensity. Colors follow the convention in Fig. 1