Figure 9

Effect of lesion size and intensity on the compound action potential in the presence of threshold compensation. The compound action potential is shown (top) for an intact axon with N̅=100 internodes (black line) and two lesion frequencies \(p_{L}= 0.01\) (red) and \(p_{L}=0.2\) (blue). Intensity of damage and lesion size are kept fixed (50% damage, \(k=1\)). The time course is normalized to the peak amplitude of intact axons (bottom). (b) Compound action potential for changing lesion intensity 70% damage (red) and 97% damage (blue) while keeping size and frequency of lesions fixed (\(p_{L}=0.1\), \(k=1\)). (c) The Full Width at Half Maximum (FWHM) of the compound action potential as a function of damage intensity for rare and small lesions (gray, \(p_{L}=0.1\), \(k=1\)) and frequent but small lesions (blue, \(p_{L}=0.2\), \(k=1\))