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Figure 1 | The Journal of Mathematical Neuroscience

Figure 1

From: A model of on/off transitions in neurons of the deep cerebellar nuclei: deciphering the underlying ionic mechanisms

Figure 1

A–C. Basic I/O relationship of the model probed with injected pulses of hyperpolarizing current (300 ms duration). Amplitudes from left to right: \(-2\times 10^{3}\), \(-2.5 \times 10^{3}\) and \(-3.9 \times 10^{3}~\mbox{nAcm}^{-2}\). A: membrane potential. B: cytoplasmic free Ca2+ concentration [Ca]. C: instantaneous spiking frequency. D. Transition of the model from silent mode to firing mode triggered by hyperpolarizing (D1, \(-0.5 \times 10^{3}~\mbox{nAcm}^{-2}\)) and depolarizing current pulses (D2, \(0.75 \times 10^{3}~\mbox{Acm}^{-2}\)). Bottom: corresponding time course of the \(h_{\text{NaV}}\) (\(I_{\text{Na}}\) inactivation) and \(m_{\text{Kdr}}\) (\(I_{\text{Kdr}}\) activation) variables

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