Table 1 List of parameter values. The abbreviation ‘cstd’ indicates that the value was constrained to reproduce experimental dynamics of DCN
Parameter | Value | Reference |
|---|---|---|
Calcium ions dynamics | ||
\(R_{c}\) | \(5 \times 10^{ - 4}~\mbox{cm}\) | [26] |
δ | \(3 \times 10^{ - 4}~\mbox{cm}\) | |
k | \(10^{ - 2}~\mbox{cm/s}\) | |
\([ B ]_{T}\) | \(1.5 \times 10^{2}~\mu \mbox{M}\) | |
\(K_{D}\) | \(1~\mu \mbox{M}\) | |
Membrane potential dynamics | ||
C | \(1~\mu \mbox{F/cm}^{2}\) | [25] |
Membrane ion currents | ||
Maximum conductances and permeabilities | ||
\(g_{\text{L}}\) | \(2 \times 10^{1}~\mu \mbox{S/cm}^{2}\) | cstd |
\(g_{\text{NaV}}\) | \(5 \times 10^{3}~\mu \mbox{S/cm}^{2}\) | |
\(g_{\text{Kdr}}\) | \(4.5 \times 10^{3}~\mu \mbox{S/cm}^{2}\) | |
\(g_{\text{TCN}}\) | \(4.5 \times 10^{1}~\mu \mbox{S/cm}^{2}\) | |
\(g_{\text{KCa}}\) | \(10~\mu \mbox{S/cm}^{2}\) | |
\(P_{\text{CaH}}\) | \(2 \times 10^{ - 4}~\mbox{cm/s}\) | |
\(P_{\text{CaT}}\) | \(7 \times 10^{ - 4}~\mbox{cm/s}\) | |
Nernst potential | ||
\(E_{\text{L}}\) | \(- 60~\mbox{mV}\) | cstd |
\(E_{\text{Na}}\) | \(+ 86~\mbox{mV}\) | [4] |
\(E_{\text{K}}\) | \(- 80~\mbox{mV}\) | \(-83~\mbox{mV}\) in [28] |
\(E_{\text{Cl}}\) | \(- 75~\mbox{mV}\) | \(-75~\mbox{mV}\) [2] and \(-74.3~\mbox{mv}\) in [28]; however, see [5] |
\(E_{\text{TCN}}\) | \(- 34~\mbox{mV}\) | [4] |
Steady-state (in)activation parameters (mV) | ||
\(V_{m_{\text{NaV}}}\) | −32 | cstd |
\(k_{m_{\text{NaV}}}\) | 8.5 | |
\(V_{h_{\text{NaV}}}\) | −55 | |
\(k_{h_{\text{NaV}}}\) | 5.5 | [4] |
\(V_{m_{\text{Kdr}}}\) | −25 | [29] |
\(k_{m_{\text{Kdr}}}\) | 11.5 | |
\(V_{m_{\text{CaH}}}\) | −22 | cstd |
\(k_{m_{\text{CaH}}}\) | 4.53 | |
\(V_{m_{\text{CaT}}}\) | −56 | [30] |
\(k_{m_{\text{CaT}}}\) | 6.2 | |
\(V_{h_{\text{CaT}}}\) | −80 | |
\(k_{h_{\text{CaT}}}\) | 4 | |
Parameters of time constants | ||
\(\tau _{n_{\text{Kdr}}0}\) | \(0~\mbox{s}\) | cstd |
\(\tau _{n_{\text{Kdr}}1}\) | \(5.4 \times 10^{ - 3}~\mbox{s}\) | |
\(\alpha _{\tau _{n_{\text{Kdr}}}}\) | 6 × 10−1 | |
\(V_{\tau_{n_{\text{Kdr}}1}} = V_{\tau_{n_{\text{Kdr}}2}}\) | \(- 30~\mbox{mV}\) | |
\(k_{\tau_{n_{\text{Kdr}}1}} = k_{\tau_{n_{\text{Kdr}}2}}\) | \(25~\mbox{mV}\) | |
\(\tau _{h_{\text{NaV}}0}\) | \(5 \times 10^{ - 3}~\mbox{s}\) | |
\(\tau _{h_{\text{NaV}}1}\) | \(3 \times 10^{ - 2}~\mbox{s}\) | |
\(\alpha _{\tau _{h_{\text{NaV}}}}\) | 1 | |
\(V_{\tau_{h_{\text{NaV}}1}} = V_{\tau_{h_{\text{NaV}}2}}\) | \(- 65~\mbox{mV}\) | |
\(k_{\tau_{h_{\text{NaV}}1}} = k_{\tau_{h_{\text{NaV}}2}}\) | \(7~\mbox{mV}\) | |
\(\tau _{m_{\text{CaT}}0}\) | \(2 \times 10^{ - 4}~\mbox{s}\) | [30] |
\(\tau _{m_{\text{CaT}}1}\) | 3.33 × 10−4 | |
\(V_{\tau_{m_{\text{CaT}}1}}\) | \(- 131~\mbox{mV}\) | |
\(k_{\tau_{m_{\text{CaT}}1}}\) | \(16.7~\mbox{mV}\) | |
\(\alpha _{\tau _{m\text{CaT}}}\) | 1 | |
\(V_{\tau_{m_{\text{CaT}}2}}\) | \(- 15.8~\mbox{mV}\) | |
\(k_{\tau_{m_{\text{CaT}}2}}\) | \(18.2~\mbox{mV}\) | |
\(\tau _{h_{\mathrm{CaH}}0}\) | \(1.2 \times 10^{ - 2}~\mbox{s}\) | cstd (to produce a \(C^{1}\) function for \(\tau _{h_{\mathrm{CaT}}}\)) |
\(\tau _{h_{\mathrm{CaH}}1}\) | \(2~\mbox{s}\) | |
\(\alpha _{\tau _{h_{\mathrm{CaT}}}}\) | 1 | |
\(V_{\tau_{h_{\mathrm{CaH}}1}} = V_{\tau_{h_{\mathrm{CaH}}2}}\) | \(- 81~\mbox{mV}\) | |
\(k_{\tau_{h_{\mathrm{CaH}}1}} = k_{\tau_{h_{\mathrm{CaH}}2}}\) | \(8~\mbox{mV}\) | |