NoiseInduced Precursors of State Transitions in the Stochastic Wilson–Cowan Model
 Ehsan Negahbani^{1}Email author,
 D. Alistair SteynRoss^{1},
 Moira L. SteynRoss^{1},
 Marcus T. Wilson^{1} and
 Jamie W. Sleigh^{2}
DOI: 10.1186/s134080150021x
© Negahbani et al.; licensee Springer. 2015
Received: 1 November 2014
Accepted: 13 March 2015
Published: 8 April 2015
Abstract
The Wilson–Cowan neural field equations describe the dynamical behavior of a 1D continuum of excitatory and inhibitory cortical neural aggregates, using a pair of coupled integrodifferential equations. Here we use bifurcation theory and smallnoise linear stochastics to study the range of a phase transitions—sudden qualitative changes in the state of a dynamical system emerging from a bifurcation—accessible to the Wilson–Cowan network. Specifically, we examine saddlenode, Hopf, Turing, and Turing–Hopf instabilities. We introduce stochasticity by adding smallamplitude spatiotemporal white noise, and analyze the resulting subthreshold fluctuations using an Ornstein–Uhlenbeck linearization. This analysis predicts divergent changes in correlation and spectral characteristics of neural activity during close approach to bifurcation from below. We validate these theoretical predictions using numerical simulations. The results demonstrate the role of noise in the emergence of critically slowed precursors in both space and time, and suggest that these earlywarning signals are a universal feature of a neural system close to bifurcation. In particular, these precursor signals are likely to have neurobiological significance as early warnings of impending state change in the cortex. We support this claim with an analysis of the in vitro local field potentials recorded from slices of mousebrain tissue. We show that in the period leading up to emergence of spontaneous seizurelike events, the mouse field potentials show a characteristic spectral focusing toward lower frequencies concomitant with a growth in fluctuation variance, consistent with critical slowing near a bifurcation point. This observation of biological criticality has clear implications regarding the feasibility of seizure prediction.
Keywords
Wilson–Cowan model Stochastics Phase transition Bifurcation Critical slowing down Hopf Saddlenode Turing Spatiotemporal patterns1 Introduction
The underlying mechanism of an abrupt state transformation in a multistable dynamical system is well described using bifurcation theory. In a close vicinity to a state change or tipping point, dynamical systems exhibit increased susceptibility and fragility, which manifests as amplification and prolongation of the system response to intrinsic or experimentally induced perturbations [1]. This phenomenon, known as critical slowing down, is accompanied by increased variance [2] and higher autocorrelations [3, 4] of state fluctuations, and growth in spectral power at characteristic frequencies. Anticipation of an imminent tipping point mandates detection of its earlywarning signals to permit timely intervention, particularly when the transition is unwelcome (e.g., species collapse) or pathological (e.g., seizure onset).
Identifying empirical indicators of an impending state transition is an area of active research across many disciplines including population ecology [5, 6], climate change [3], highvoltage engineering [7], and human behavior [8]. The notion of an abrupt phase transition, and its attendant critical signatures, has also been applied to in vivo and in vitro biological neural systems, and to simplified mathematical models of these.
Researchers have reported increased fluctuation power and slowed timescales prior to the firing of action potentials in a squid giant axon [9], and in simplified point models of resonator and integrator neuron types [10]. Similar fluctuation surges in electrical activity have been observed in intracell recordings of the prelude to the downtoup state transition for a rat neuron emerging from anesthesia [11]; in ECoG recordings during the period preceding emergence of synchronized epileptic seizure events [12]; and in EEG recordings during the natural or druginduced switching of largescale brain activity due to onset of sleep or anesthesia [13]. Although most work has focused on the temporal properties of the fluctuations, some researchers have also identified enhanced spatial correlations near a bifurcation point, for example near the transition between slowwave sleep and REM [14]; and in a 1D meanfield model of a cortex near the anesthetic critical point [15].
Our goal in the present paper is to examine critical slowing phenomena within the context of the classic Wilson–Cowan (W–C) continuum model of neural population dynamics [16, 17]. In recent work [18] we have examined the close approach to cortical phase transitions in a mature meanfield model (containing synaptic response functions, axonal wave equations, gapjunction diffusion, somatic integration) expressed as a moderately complicated set of coupled differential equations that require a minimum of 8 to 14 system variables (depending on the assumed symmetries in the couplings between the excitatory and inhibitory neural populations), making numerical and analytic manipulations unwieldy. The attraction of the W–C continuum model is its simplicity: with only two system variables (rather than 8, or 14, or more), it is possible to explore the close approach to bifurcation in a spatially extended neural model at relatively little analytic or computational cost. It is our hope that the present work might serve as a useful tutorial testbed that invites other researchers to begin investigating criticality in a simplified neural context. Although we have made extensive use of smallnoise Ornstein–Uhlenbeck (O–U) theory in our previous studies, to our knowledge this is the first time this predictive and quantitative technique has been applied to the W–C model.
Critical transitions are mediated by specific bifurcation classes, so we are motivated to examine the signs of critical slowing exhibited by each class of bifurcation that is accessible to the spatially extended Wilson–Cowan model. The specific bifurcations of interest are saddlenode, Hopf, Turing, and mixedmode Turing–Hopf interactions.
We must acknowledge the rich and extensive literature discussing temporal and spatial bifurcations in Wilson–Cowan (and W–Clike) meanfield neural models. For example, Ermentrout and Cowan [19], and more recently Bressloff [20], have explored diffusiondriven Turing instabilities in the W–C model supporting formation of stationary activity patterns that have been likened to visual hallucinations. Laing and Troy [21] derived stability conditions for socalled multibump neural activity patterns; Coombes and Laing [22] introduced delays into the W–C model and demonstrated Hopf and saddlenode bifurcations as well as bursting behavior. Close approach to the Hopf instability induces spectral growth in specific EEG frequency bands, and this idea has been investigated in an anesthesia context recently by Hutt [23] and by Hindriks and van Putten [24], with the latter work based on a thalamocortical model by Robinson et al. [25]. Hutt et al. [26–28] have studied the impact of noise on spatiotemporal instabilities in neural fields containing synaptic and transmission delays, and has established conditions for emergence of Hopf and Turing instabilities, identifying the growth of fluctuation variance on approach to bifurcation with critical slowing, and showing that under certain conditions, noise can delay Turing onset. We will revisit the latter point in the Discussion.
The paper is organized as follows: Sect. 2 describes the spatially extended Wilson–Cowan model. We locate its homogeneous stationary state and identify parameter settings that cause the state to lose stability via distinct bifurcations: saddlenode, Hopf, or Turing. We introduce additive noise, and detail a theoretical technique (Ornstein–Uhlenbeck linearization), based on the subthreshold eigenvalue structure of the steady state, that accurately predicts the statistical properties of the noiseinduced fluctuations. The results of a series of stochastic numerical experiments are presented in Sect. 3 where we demonstrate critically slowed fluctuations—emerging as patterns in time and space—for close approach to bifurcation; these emergent patterns are concordant with O–U theoretical projections. To confirm relevance of critical slowing to neuroscience, we describe electrophysiological recordings taken from slices of mousebrain tissue that have been chemically conditioned to intermittently reenter a seizurelike state. Section 4 concludes with a discussion of the apparent universality of critical slowing prior to bifurcation, and its potential usefulness as an earlywarning biosignal of impending state change in neural systems.
2 Mathematical Model
The Wilson–Cowan (W–C) model describes the average spike frequency of a neural population as a function of continuous time. The fundamental assumption is that brain activity can be described in terms of interactions between excitatory and inhibitory populations, so the state variables for the model are E and I, the excitatory and inhibitory spikerates, respectively. Based on known neuroanatomy, Wilson and Cowan assumed a random, dense connectivity between individual cells, allowing at least one connection between any two cells in the network.
Wilson and Cowan neglected spatial interactions in their original 1972 paper [16] in order to investigate temporal dynamics of a localized cortical column; they then extended their model to spatially distributed neural populations in their 1973 paper [17], and modeled 1D rods and 2D sheets of cortical and thalamic tissue.
In this section we introduce the W–C model equations in both their spatially homogeneous and their spatially varying 1D forms, define their stationary states, and perform a linear stability analysis about these stationary states in Fourier (wavenumber q) domain to extract the eigenvaluevs.q dispersion curves, enabling us to identify potential bifurcations points at which stability of a given stationary state is predicted to disappear. We then introduce stochasticity into the model by adding smallamplitude spatiotemporal white noises, and compute a set of subthreshold fluctuation statistics (autocorrelations, temporal and spatial spectral densities) that allow us to quantify the expected alterations in fluctuation properties as the W–C model closely approaches a given critical point. We then detail the algorithm used to numerically integrate the stochastic W–C equations in one spatial dimension.
2.1 Simplified Wilson–Cowan Equations
2.2 Homogeneous Wilson–Cowan Limit
Symbol definitions and parameter values for 1D Wilson–Cowan model
Symbol  Description  Value (homogeneous)  Value (space dependent)  Unit 

E, I  Excitatory and inhibitory firing rates  (ms)^{−1}  
\(S_{E}\), \(S_{I}\)  Sigmoid functions  (ms)^{−1}  
\(\tau_{E,I}\)  E and I time constants  10, 8  10, 8  ms 
\(b_{EE, EI, IE, II}\)  Synaptic coupling strength  18, 10, 10, 0  18, 10, 19, 0  mV⋅ms 
\(\sigma_{EE}\)  E→E space constant  50  43, 50  μm 
\(\sigma_{EI}\)  E→I space constant  110  [42–148.5]  μm 
\(\sigma_{IE}\)  I→E space constant  110  [42–148.5]  μm 
\(\sigma_{II}\)  I→I space constant  20  20  μm 
\(S_{E,I}^{\max}\)  Maximum firing rate  0.1, 0.15  0.1, 0.15  (ms)^{−1} 
\(a_{E,I}\)  Sigmoid slope at threshold  9  9  (mV)^{−1} 
\(\theta_{E,I}\)  Halfmaximum firing threshold  2.2  2.2  mV 
P, Q  Exogenous voltage inputs  [0.9–3.3], 1.35  [0.9–3.3], 1.35  mV 
2.3 SpaceDependent Wilson–Cowan Model of 1D Cortical Rod
2.4 Steady States of Deterministic System
2.5 Linear Stability Analysis of Deterministic Model
We analyze the spaceindependent case by setting \(q=0\), and plotting the eigenvalue spectrum as a function of excitatory voltage drive P; see Fig. 1(b), (c). Two bifurcation types are evident: emergence of multiple states via saddlenode (SN) bifurcation, and loss of stability of the top branch via Hopf bifurcation (HB).
2.6 Dispersion Curves of SpaceDependent Model
2.7 Stochastic Model and Subthreshold Fluctuation Statistics
2.7.1 Spatial Power Spectral Density
The spatial variance of the E–E fluctuations is estimated by evaluating the integral \(\int_{\infty}^{\infty}[\tilde {\mathbf{G}}(q)]_{11}\,dq\); meanwhile the spatial autocorrelation of these fluctuations is extracted from the inverse Fourier transform, \([\mathbf{G}(x)]_{11} = \mathcal{F}^{1}[\tilde {\mathbf{G}}(q)]_{11}\).
2.7.2 Temporal Autocorrelation and Variance
The temporal variance is the value of temporal autocorrelation at \(\tau = 0\mbox{ ms}\).
2.8 Numerical Solution of the Stochastic W–C Equations
A fixed timestep Euler algorithm was used to integrate the equations: we used \(\Delta t = 0.1\mbox{ ms}\) for saddlenode analysis; 0.005 ms for other instabilities. Initial values of the E and I firing activity were set to the steady states values computed numerically from the intersection of the excitatory and inhibitory nullclines. Simulation durations were 10, 1.0, 5.0, and 0.5 s for saddlenode, Hopf, Turing and Turing–Hopf bifurcations, respectively. Spatial resolution was $\mathrm{\Delta}x=1.5\text{\mu m}$ for all simulations. Field lengths of \(L=3, 1, 6, 6\mbox{ mm}\) were used for simulation of saddlenode, Hopf, Turing, and TuringHopf bifurcations respectively. Appendix B contains demonstration code.
3 Results
In this section we describe the variety of distinct bifurcations accessible to a deterministic Wilson–Cowan model, then run a series of numerical simulations of the stochastic W–C model placed close to bifurcation. We analyze the noiseinduced subthreshold fluctuation statistics, and compare the numerical results with linear Ornstein–Uhlenbeck theoretical predictions, showing excellent agreement. To demonstrate relevance to real neuroscience, we report some new results from our electrophysiology laboratory showing precursor electrical activity in slices of rodent braintissue that have been chemically treated to generate infrequent spontaneous seizures.
3.1 Bifurcations Accessible to the Deterministic 1D Wilson–Cowan Model
Four instability bifurcations of the deterministic Wilson–Cowan cortex are demonstrated here: saddlenode, Hopf, Turing, and interacting Turing–Hopf; and in the section following, we will explore and quantify the noiseinduced fluctuation responses of the cortex during close approach to each bifurcation point. Note that the oscillatory Turing instability (also known as a wave instability) is missing from this list of accessible bifurcations; this is because our implementation of the W–C model contains only two interacting components (E and I), while a minimum of three components are needed to support emergence of traveling or standing waves [33–35]. We return to this point briefly in the Discussion.
3.1.1 SaddleNode
A saddlenode bifurcation occurs when the midbranch of the Sbend curve of steady states collides with the bottom branch and annihilates at \(P_{\mathrm{SN}}\simeq1.7892426576\mbox{ mV}\): see Fig. 1(a). This bifurcation results in the disappearance of a pair of steady states, forcing the system to move to an alternate state resulting in a qualitative change in system dynamics.
3.1.2 Hopf
A Hopf bifurcation occurs when the real part of the complex eigenvalue pair changes sign at \(P_{\mathrm{HB}}\simeq2.1971513755\mbox{ mV}\) as indicated in Fig. 1(b), (c). This bifurcation also changes the qualitative behavior of the cortex, leading to emergence of temporal oscillations.
3.1.3 Turing
The dispersion curves for \(P=2.34\mbox{ mV}\) are plotted in Fig. 2(a). Boosting the inhibitory synaptic range constants \(\sigma_{EI}\) and \(\sigma_{IE}\) elevates the dispersion curves. When ${\sigma}_{EI,IE}=200\text{\mu m}$, parts of the αcurve exhibit positive excursions predicting the formation of spatial Turing structures with spatial frequency \(q/2\pi\simeq1.6\mbox{ waves/mm}\). The time–space graph of Fig. 2(b) shows the simulation results from the corresponding stochastic model. Initialized at the homogeneous deterministic steady state, the network spontaneously evolves into a spatially periodic structure. Although the pattern first emerges as a small sinusoidal oscillation in space whose frequency matches that of the dominant mode, the pattern rapidly becomes strongly nonsinusoidal as it grows, with nonlinear contributions from a broad range of wavenumbers (\(1.1 \lesssim q/2\pi \lesssim3\mbox{ mm}^{1}\)). We note that linear eigenvalue analysis is only valid while the fluctuations remain small and sinusoidal, and it cannot predict the form of the fully evolved nonlinear spatial structure.
3.1.4 Turing–Hopf
The Turing–Hopf spatiotemporal instability results from the interaction between Turing and Hopf bifurcations, so requires that the conditions for both bifurcations be met simultaneously—i.e., the system should be close to an HB point, and the corresponding α dispersion curve should have a positive excursion at some nonzero qvalue. We select \(P=2\mbox{ mV}\) to put the system in an unstable Hopf mode (green circle in Fig. 3(a)), and we set ${\sigma}_{EI,IE}=112\text{\mu m}$ to induce a Turing instability (positive α for \(q\neq0\)). The red curve of Fig. 3(b) predicts a global (\(q=0\)) mode of temporal frequency \(f\simeq47\mbox{ HZ}\). We simulate the corresponding stochastic model and plot the spatiotemporal graphs of the 1D cortex in Fig. 3(c) (bird’seye view) and (d) (3D view) showing the Turing–Hopf interaction. The temporal Hopf oscillations dominate first, then the Turing pattern emerges, leading to development of mixedmode oscillations.
In the following sections we drive the subthreshold system toward distinct bifurcation points, limiting ourselves to small noiseinduced subthreshold fluctuations that approach, but do not cross, bifurcation threshold. We focus on the altering spectral characteristics of these fluctuations, looking for evidence of critical slowing.
3.2 Close Approach to State Transition in the Stochastic W–C Model
3.2.1 Homogeneous Steady States and Dispersion Curves

A peak at the \(q=0\) axis can be predictive of saddlenode or Hopf, with expected temporal frequency that can be read from the \(\omega /2\pi\)curve.

A peak at \(q/2\pi\neq0\) suggests a Turing bifurcation at this nonzero spatial frequency.

The presence of two peaks, one at \(q/2\pi=0\) and the other at \(q/2\pi\neq0\), predicts a mixedmode Turing–Hopf spatiotemporal pattern.
The dispersion curves predict a “dcresonant” frequency in space and time for saddlenode mode (Fig. 4(a)), while the approach to Hopf bifurcation is accompanied with temporal oscillations of frequencies \(\omega/2\pi=44.04, 45.45, 46.11\mbox{ Hz}\) (Fig. 4(b)). Spatial frequencies of \(q/2\pi=2.27, 2.18, 2.18\mbox{ waves/mm}\) are predicted for neural activity along the cortical rod when Turing instability is approached (Fig. 4(c)). Note that the strong dominance of Turing over Hopf instability (compare peak values of αcurve at \(q=0\) axis and at \(q/2\pi\simeq2.7\mbox{ waves/mm}\)) suppresses the formation of temporal oscillations in Turing mode. In contrast, the dispersion curves in Fig. 4(d) feature dual αcurve peaks of comparable heights, suggesting the emergence of mixedmode oscillations with frequencies of \(\omega/2\pi=44.02, 45.145, 46.08\mbox{ Hz}\) and \(q/2\pi \simeq2.64, 2.64, 2.61\mbox{ waves/mm}\) in time and space, respectively.
3.2.2 Numerical Study and Ornstein–Uhlenbeck Predictions
For a saddlenode, the experimental tACC is the average of temporal autocorrelations of noiseinduced E fluctuations obtained from 300 elements evenly distributed along the cortical rod (some of these traces are superimposed in Fig. 6(a)). The theoretical tACC (thick red curve) shows good agreement with experiment. We observe a pronounced widening of the autocorrelation curve, indicating a strong increase in correlation time, as the saddlenode annihilation point is approached. The unexpected appearance of sidelobe oscillations in the experimental tACC curves is an artifact caused by the finite length of the rod and the finite duration of the simulations: these “oscillations” damp out for longer rod lengths and simulation durations. A small growth in temporal variance (equal to tACC value at the origin) is also evident.
Theoretical and experimental temporal autocorrelations of Efluctuations close to the Hopf bifurcation are displayed in Fig. 6(b). Growth in the amplitude of tACC at the origin and the side lobes is evident as the system is driven toward the Hopf instability. The experimental autocorrelation function is computed as the average of individual tACCs (thin blue traces) from 100 sample points evenly distributed along the cortical rod. The experiments confirm the emergence and amplification of temporal oscillations of frequency \(f\simeq46\mbox{ Hz}\).
We analyze the spatial patterns of Turing and mixedmode oscillations in terms of the spatial spectral density of the Efluctuations. The sPSD (theoretical and experimental) for the Turing instability is plotted in Fig. 6(c). Here we have used the Evalues of the entire 1D rod at 10,000 instants evenly distributed between \(t=0\) and \(t=5\mbox{ s}\) to compute an average experimental sPSD. We see that approach to the Turing threshold is accompanied by a significant increase in the peak value of sPSD at spatial frequency \(q/2\pi\simeq2.2\mbox{ waves/mm}\), as predicted in the dispersion curves of Fig. 4(c).
We plot the theoretical and experimental sPSD for mixedmode oscillations in Fig. 6(d). As expected from Fig. 4(d), twin peaks emerge at \(q=0\) and \(q/2\pi\simeq2.6\mbox{ waves/mm}\), and these grow on approach to the threshold of the Turing–Hopf instability. The temporal dynamics prior to the mixedmode instability is also quantified in this figure using tACC of the Efluctuations. The results are similar to the Hopf case, showing an increased amplitude of tACC at the origin and the side lobes with temporal frequency \(f\simeq 45\mbox{ Hz}\). Note the discrepancy between theoretical and experimental results when the state is very close to the threshold of the mixedmode instability. We propose that this discrepancy arises from nonlinear interactions between the two types of bifurcation, making linear stability predictions less accurate.
3.3 In Vitro Evidence for Critical Slowing Near Bifurcation in a Brain Slice
The stochastic Wilson–Cowan model runs, supported by linear Ornstein–Uhlenbeck analysis, are unambiguous in their predictions: irrespective of bifurcation type, noiseinduced fluctuations are expected to increase in intensity while becoming more prolonged in space and time (i.e., become critically slowed) during close approach to the bifurcation point. Thus, near a given critical point, we can expect specific universal characteristics to emerge in the statistical properties of the fluctuations. But these mathematical predictions are based on an idealized cortex—does the notion of criticality have any significance for real biological organisms in general and for neuroscience in particular?
To address this question, we have closely examined the spontaneous electrical activity in slices of mousebrain tissue (from the hippocampus) perfused by an artificial cerebral spinal fluid containing zero concentration of magnesium ions (this causes NMDA channels to open) to which is added a low concentration of carbachol (to activate acetylcholine receptors) (see Ch. 7 of [36] for details). This preparation encourages spontaneous formation of transient avalanches of electrical activity in the slice, which have been likened to epileptic seizures, so they are referred to as seizurelike events (SLEs). If the emergence of an SLE represents a transition through a neural bifurcation point, then one would expect to see evidence of criticality in the local field potentials in the period leading up to the event.
These observations provide pleasing qualitative support for the conjecture that seizure can be modeled as a neural bifurcation showing precursive characteristics of critical slowing and growing of fluctuation activity.
4 Discussion
This paper adopts a lightly modified form of the onedimensional E–I Wilson–Cowan network equations as an ideal testbed for investigating subthreshold dynamics prior to state transition. We used linear stability analysis to predict activity patterns emerging from the stationary homogeneous state of the W–C cortex. With appropriate selection of parameters, we obtain different patterns associated with the different bifurcations: bistability (saddlenode), bulk oscillations (Hopf), stationary patterns (Turing), and drifting patterns (Turing–Hopf). We quantified the impact of spatiotemporal noise on the homogeneous steady state by performing a linearization to derive an effective spatially extended Ornstein–Uhlenbeck process, allowing us to approximate the spatial power spectral density and correlation functions for the stochastic system. Near the saddlenode, the autocorrelation curve widens, indicating an increase in correlation time. Near the Hopf case, the autocorrelation grows at the origin and side lobes associated with the oscillation frequency. Near the Turing bifurcation, the power spectrum grows at the bifurcation pattern frequency. Finally, near the Turing–Hopf case, both the power spectrum and the autocorrelation grow at the onsetting pattern’s chosen frequency.
Missing from this list of bifurcations of the W–C network is the wave instability arising from an oscillating Turing. This is because, in the absence of delays, it is not possible to generate an oscillating Turing in the twovariable W–C model: such an instability can only occur in reaction–diffusion systems of three or more morphogens. This was first pointed out by Turing in his foundational 1952 paper [33], and more recent papers have used this fact to extract mathematical conditions for the occurrence of a wave instability in threecomponent reaction–diffusion systems [34, 35].
Hutt et al. [27, 28] have shown that under certain specific conditions, the presence of noise can delay the onset of a Turing bifurcation in a neural field. The delay occurs if the noise is “global” (uncorrelated in time while constant in space) since it induces a form of spacelocking of field activity; but no such delay was reported in the case of fully uncorrelated noise (i.e., noise which is white in both space and time). Because all of our numerical simulations use white noise that is completely uncorrelated in space and time, our experiments of Fig. 5(c) near the Turing critical point of Fig. 4(c) do not exhibit any onset delay, and thus the stochastic simulations for close approach to the Turing bifurcation for the 1D cortex are in excellent agreement with the Chaturvedi et al. [31] Ornstein–Uhlenbeck predictions for whitenoiseinduced spatial power spectral densities (compare black and red traces of Fig. 6(c)).
The fact that we are able to predict accurately the nonlinear growth in system responsiveness using linear stochastic theory is both surprising and satisfying. The success of linear stochastics arises because the noise stimulus and the resulting fluctuation amplitudes are small, so the eigenvalues obtained from linear stability analysis provide a good characterization of the deterministic response to the train of stochastic impulses from the noise. The critical slowing near threshold is governed by the weakening decayrate of the dominant eigenvalue: at the critical point, the decayrate is zero, so the perturbation response becomes infinitely prolonged.
The observed growth and widening of temporal autocorrelations and amplification of power at specific frequencies near instability onset are characteristic of systems approaching phase transition. Dramatic switching of brain activity to a new state is observed in both healthy and pathological cases, for example during wake–sleep and wake–anesthesia cycles, and at seizure onset. It has been proposed recently by Jirsa et al. that different bifurcation types may be responsible for these neural state transitions [37]. Indeed, the paradoxical boost in neural activity prior to anesthesiainduced loss of consciousness [38] may be a manifestation of critical slowing prior to loss of consciousness [39, 40].
The translation of our Wilson–Cowan model predictions—namely critical slowing near bifurcation onset—into real clinical applications will not be trivial. Under the very strictly controlled conditions of the in vitro brain slice, we were only able to see clear frequency changes in our local field potential recordings (Fig. 9) after going to the utmost lengths to suppress experimental noise (such as electrode drift, electromagnetic interference, vibrationinduced artifacts, ground loops). This is because the subthreshold fluctuations are orders of magnitude smaller than the huge nonlinear oscillations that erupt beyond the bifurcation point. Nevertheless, our model does indicate an alternative approach to seizure prediction: current attempts at seizure prediction have concentrated on the detection of very high frequency oscillations as seizure precursors [41]; we suggest that it might be profitable to look instead at changes in very low temporal and spatial frequencies as indicators of imminent seizure.
Declarations
Acknowledgements
We acknowledge support from the Marsden Fund of the Royal Society of New Zealand. We thank Dr Logan Voss for his guidance with the in vitro brainslice experiments. We also appreciate the insightful comments and guidance from two referees.
Open Access This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Authors’ Affiliations
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