Fig. 13

Hodgkin–Huxley sodium channel: edge importance. This figure shows edge importance $R_k$ as a function of voltage in the range $[-100,100]\text{ mV}$ for each reaction $k\in \{1,\dots ,20\}$. The magenta curve corresponds to edges 11 and 12 and the yellow curve corresponds to edges 19 and 20 (transitions between the conducting state 8 and its two nearest neighbors, states 7 and 4, respectively). Note that $R_{11}=R_{12}$ (magenta) has the highest edge importance in the voltage range $[-100,-25]\text{ mV}$ and $R_{19}=R_{20}$ (yellow) has the highest value in the range $[-25,100]\text{ mV}$