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Fig. 5 | The Journal of Mathematical Neuroscience

Fig. 5

From: A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model

Fig. 5

Comparison of the effects of a GABA bolus on the feedforward and bilaterally coupled neuron–astrocyte mass models. Bifurcation diagrams according to p (top panels) computed for the model without feedback for all t (a1) and for the model with feedback at \(t=0~\mbox{s}\) (b1) and \(t=30~\mbox{s}\) (b2). Time series (bottom panels) corresponding to LFP, glutamate and GABA extracellular concentrations and time variations of \(p_{{\mathrm{SNIC}}}\) generated by the models without feedback (left) and with feedback (right). The purple lines on the bifurcation diagrams materialize the fixed value of input p. The dark red arrows above each time series materialize the time of GABA bolus injection

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