Articles

Phase-dependence of response curves to deep brain stimulation and their relationship: from essential tremor patient data to a Wilson–Cowan model

Essential tremor manifests predominantly as a tremor of the upper limbs. One therapy option is high-frequency deep brain stimulation, which continuously delivers electrical stimulation to the ventral intermedi...

Authors: Benoit Duchet, Gihan Weerasinghe, Hayriye Cagnan, Peter Brown, Christian Bick and Rafal Bogacz

Sparse identification of contrast gain control in the fruit fly photoreceptor and amacrine cell layer

The fruit fly’s natural visual environment is often characterized by light intensities ranging across several orders of magnitude and by rapidly varying contrast across space and time. Fruit fly photoreceptors...

Authors: Aurel A. Lazar, Nikul H. Ukani and Yiyin Zhou

The hyperbolic model for edge and texture detection in the primary visual cortex

The modeling of neural fields in the visual cortex involves geometrical structures which describe in mathematical formalism the functional architecture of this cortical area. The case of contour detection and ...

Authors: Pascal Chossat

Exact solutions to cable equations in branching neurons with tapering dendrites

Neurons are biological cells with uniquely complex dendritic morphologies that are not present in other cell types. Electrical signals in a neuron with branching dendrites can be studied by cable theory which ...

Authors: Lu Yihe and Yulia Timofeeva

Greedy low-rank algorithm for spatial connectome regression

Recovering brain connectivity from tract tracing data is an important computational problem in the neurosciences. Mesoscopic connectome reconstruction was previously formulated as a structured matrix regressio...

Authors: Patrick Kürschner, Sergey Dolgov, Kameron Decker Harris and Peter Benner

Correction to: Linking demyelination to compound action potential dispersion with a spike-diffuse-spike approach

Following publication of the original article [1], the authors noticed a mistake in the first paragraph within “Altered propagation”.

Authors: Richard Naud and André Longtin

The uncoupling limit of identical Hopf bifurcations with an application to perceptual bistability

We study the dynamics arising when two identical oscillators are coupled near a Hopf bifurcation where we assume a parameter ϵ uncouples the system at

Authors: Alberto Pérez-Cervera, Peter Ashwin, Gemma Huguet, Tere M. Seara and James Rankin

Data-driven inference for stationary jump-diffusion processes with application to membrane voltage fluctuations in pyramidal neurons

The emergent activity of biological systems can often be represented as low-dimensional, Langevin-type stochastic differential equations. In certain systems, however, large and abrupt events occur and violate ...

Authors: Alexandre Melanson and André Longtin

Drift–diffusion models for multiple-alternative forced-choice decision making

The canonical computational model for the cognitive process underlying two-alternative forced-choice decision making is the so-called drift–diffusion model (DDM). In this model, a decision variable keeps track...

Authors: Alex Roxin

A modified Hodgkin–Huxley model to show the effect of motor cortex stimulation on the trigeminal neuralgia network

Trigeminal neuralgia (TN) is a severe neuropathic pain, which has an electric shock-like characteristic. There are some common treatments for this pain such as medicine, microvascular decompression or radio fr...

Authors: Mohammadreza Khodashenas, Golnaz Baghdadi and Farzad Towhidkhah

Linking demyelination to compound action potential dispersion with a spike-diffuse-spike approach

To establish and exploit novel biomarkers of demyelinating diseases requires a mechanistic understanding of axonal propagation. Here, we present a novel computational framework called the stochastic spike-diff...

Authors: Richard Naud and André Longtin

Efficient calculation of heterogeneous non-equilibrium statistics in coupled firing-rate models

Understanding nervous system function requires careful study of transient (non-equilibrium) neural response to rapidly changing, noisy input from the outside world. Such neural response results from dynamic in...

Authors: Cheng Ly, Woodrow L. Shew and Andrea K. Barreiro

Special Issue from the 2017 International Conference on Mathematical Neuroscience

The ongoing acquisition of large and multifaceted data sets in neuroscience requires new mathematical tools for quantitatively grounding these experimental findings. Since 2015, the International Conference on...

Authors: Zachary P. Kilpatrick, Julijana Gjorgjieva and Robert Rosenbaum

M-Current Expands the Range of Gamma Frequency Inputs to Which a Neuronal Target Entrains

Theta (4–8 Hz) and gamma (30–80 Hz) rhythms in the brain are commonly associated with memory and learning (Kahana in J Neurosci 26:1669–1672, 2006; Quilichini et al. in J Neurosci 30:11128–11142, 2010). The preci...

Authors: Yujia Zhou, Theodore Vo, Horacio G. Rotstein, Michelle M. McCarthy and Nancy Kopell

Stochastic Hybrid Systems in Cellular Neuroscience

We review recent work on the theory and applications of stochastic hybrid systems in cellular neuroscience. A stochastic hybrid system or piecewise deterministic Markov process involves the coupling between a ...

Authors: Paul C. Bressloff and James N. Maclaurin

Data Assimilation Methods for Neuronal State and Parameter Estimation

This tutorial illustrates the use of data assimilation algorithms to estimate unobserved variables and unknown parameters of conductance-based neuronal models. Modern data assimilation (DA) techniques are wide...

Authors: Matthew J. Moye and Casey O. Diekman

Bifurcations of Limit Cycles in a Reduced Model of the Xenopus Tadpole Central Pattern Generator

We present the study of a minimal microcircuit controlling locomotion in two-day-old Xenopus tadpoles. During swimming, neurons in the spinal central pattern generator (CPG) generate anti-phase oscillations betwe...

Authors: Andrea Ferrario, Robert Merrison-Hort, Stephen R. Soffe, Wen-Chang Li and Roman Borisyuk

What Is Required for Neuronal Calcium Waves? A Numerical Parameter Study

Neuronal calcium signals propagating by simple diffusion and reaction with mobile and stationary buffers are limited to cellular microdomains. The distance intracellular calcium signals can travel may be signi...

Authors: Markus Breit and Gillian Queisser

Investigating the Correlation–Firing Rate Relationship in Heterogeneous Recurrent Networks

The structure of spiking activity in cortical networks has important implications for how the brain ultimately codes sensory signals. However, our understanding of how network and intrinsic cellular mechanisms...

Authors: Andrea K. Barreiro and Cheng Ly

Effect of Neuromodulation of Short-term Plasticity on Information Processing in Hippocampal Interneuron Synapses

Neurons in a micro-circuit connected by chemical synapses can have their connectivity affected by the prior activity of the cells. The number of synapses available for releasing neurotransmitter can be decreas...

Authors: Elham Bayat Mokhtari, J. Josh Lawrence and Emily F. Stone

Analysis of an Attractor Neural Network’s Response to Conflicting External Inputs

The theory of attractor neural networks has been influential in our understanding of the neural processes underlying spatial, declarative, and episodic memory. Many theoretical studies focus on the inherent pr...

Authors: Kathryn Hedrick and Kechen Zhang

Saddle Slow Manifolds and Canard Orbits in \(\mathbb{R}^{4}\) and Application to the Full Hodgkin–Huxley Model

Many physiological phenomena have the property that some variables evolve much faster than others. For example, neuron models typically involve observable differences in time scales. The Hodgkin–Huxley model i...

Authors: Cris R. Hasan, Bernd Krauskopf and Hinke M. Osinga

The Dynamics of Networks of Identical Theta Neurons

We consider finite and infinite all-to-all coupled networks of identical theta neurons. Two types of synaptic interactions are investigated: instantaneous and delayed (via first-order synaptic processing). Ext...

Authors: Carlo R. Laing

Kernel Reconstruction for Delayed Neural Field Equations

Understanding the neural field activity for realistic living systems is a challenging task in contemporary neuroscience. Neural fields have been studied and developed theoretically and numerically with conside...

Authors: Jehan Alswaihli, Roland Potthast, Ingo Bojak, Douglas Saddy and Axel Hutt

Sparse Functional Identification of Complex Cells from Spike Times and the Decoding of Visual Stimuli

We investigate the sparse functional identification of complex cells and the decoding of spatio-temporal visual stimuli encoded by an ensemble of complex cells. The reconstruction algorithm is formulated as a ...

Authors: Aurel A. Lazar, Nikul H. Ukani and Yiyin Zhou

Robust Exponential Memory in Hopfield Networks

The Hopfield recurrent neural network is a classical auto-associative model of memory, in which collections of symmetrically coupled McCulloch–Pitts binary neurons interact to perform emergent computation. Alt...

Authors: Christopher J. Hillar and Ngoc M. Tran

A Rate-Reduced Neuron Model for Complex Spiking Behavior

We present a simple rate-reduced neuron model that captures a wide range of complex, biologically plausible, and physiologically relevant spiking behavior. This includes spike-frequency adaptation, postinhibit...

Authors: Koen Dijkstra, Yuri A. Kuznetsov, Michel J. A. M. van Putten and Stephan A. van Gils

The Dynamics of Neural Fields on Bounded Domains: An Interface Approach for Dirichlet Boundary Conditions

Continuum neural field equations model the large-scale spatio-temporal dynamics of interacting neurons on a cortical surface. They have been extensively studied, both analytically and numerically, on bounded a...

Authors: Aytül Gökçe, Daniele Avitabile and Stephen Coombes

Fundamental Limits of Forced Asynchronous Spiking with Integrate and Fire Dynamics

Authors: Anirban Nandi, Heinz Schättler, Jason T. Ritt and ShiNung Ching

Symmetries Constrain Dynamics in a Family of Balanced Neural Networks

We examine a family of random firing-rate neural networks in which we enforce the neurobiological constraint of Dale’s Law—each neuron makes either excitatory or inhibitory connections onto its post-synaptic t...

Authors: Andrea K. Barreiro, J. Nathan Kutz and Eli Shlizerman

An Analysis of Waves Underlying Grid Cell Firing in the Medial Enthorinal Cortex

Layer II stellate cells in the medial enthorinal cortex (MEC) express hyperpolarisation-activated cyclic-nucleotide-gated (HCN) channels that allow for rebound spiking via an ...

Authors: Mayte Bonilla-Quintana, Kyle C. A. Wedgwood, Reuben D. O’Dea and Stephen Coombes

A Stochastic Version of the Jansen and Rit Neural Mass Model: Analysis and Numerics

Neural mass models provide a useful framework for modelling mesoscopic neural dynamics and in this article we consider the Jansen and Rit neural mass model (JR-NMM). We formulate a stochastic version of it whi...

Authors: Markus Ableidinger, Evelyn Buckwar and Harald Hinterleitner

Fast–Slow Bursters in the Unfolding of a High Codimension Singularity and the Ultra-slow Transitions of Classes

Bursting is a phenomenon found in a variety of physical and biological systems. For example, in neuroscience, bursting is believed to play a key role in the way information is transferred in the nervous system...

Authors: Maria Luisa Saggio, Andreas Spiegler, Christophe Bernard and Viktor K. Jirsa

Regularization of Ill-Posed Point Neuron Models

Point neuron models with a Heaviside firing rate function can be ill-posed. That is, the initial-condition-to-solution map might become discontinuous in finite time. If a Lipschitz continuous but steep firing rat...

Authors: Bjørn Fredrik Nielsen

Finite-Size Effects on Traveling Wave Solutions to Neural Field Equations

Neural field equations are used to describe the spatio-temporal evolution of the activity in a network of synaptically coupled populations of neurons in the continuum limit. Their heuristic derivation involves...

Authors: Eva Lang and Wilhelm Stannat

How Adaptation Makes Low Firing Rates Robust

Low frequency firing is modeled by Type 1 neurons with a SNIC, but, because of the vertical slope of the square-root-like f–I curve, low f only occurs over a narrow range of I. When an adaptive current is added, ...

Authors: Arthur S. Sherman and Joon Ha

Timescales and Mechanisms of Sigh-Like Bursting and Spiking in Models of Rhythmic Respiratory Neurons

Neural networks generate a variety of rhythmic activity patterns, often involving different timescales. One example arises in the respiratory network in the pre-Bötzinger complex of the mammalian brainstem, wh...

Authors: Yangyang Wang and Jonathan E. Rubin

Emergent Dynamical Properties of the BCM Learning Rule

The Bienenstock–Cooper–Munro (BCM) learning rule provides a simple setup for synaptic modification that combines a Hebbian product rule with a homeostatic mechanism that keeps the weights bounded. The homeosta...

Authors: Lawrence C. Udeigwe, Paul W. Munro and G. Bard Ermentrout

Stable Control of Firing Rate Mean and Variance by Dual Homeostatic Mechanisms

Homeostatic processes that provide negative feedback to regulate neuronal firing rates are essential for normal brain function. Indeed, multiple parameters of individual neurons, including the scale of afferen...

Authors: Jonathan Cannon and Paul Miller

A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model

Recent experimental evidence on the clustering of glutamate and GABA transporters on astrocytic processes surrounding synaptic terminals pose the question of the functional relevance of the astrocytes in the r...

Authors: Aurélie Garnier, Alexandre Vidal and Habib Benali

Analytic Modeling of Neural Tissue: I. A Spherical Bidomain

Presented here is a model of neural tissue in a conductive medium stimulated by externally injected currents. The tissue is described as a conductively isotropic bidomain, i.e. comprised of intra and extracell...

Authors: Benjamin L. Schwartz, Munish Chauhan and Rosalind J. Sadleir

Responses of Leaky Integrate-and-Fire Neurons to a Plurality of Stimuli in Their Receptive Fields

A fundamental question concerning the way the visual world is represented in our brain is how a cortical cell responds when its classical receptive field contains a plurality of stimuli. Two opposing models ha...

Authors: Kang Li, Claus Bundesen and Susanne Ditlevsen

Ill-Posed Point Neuron Models

We show that point-neuron models with a Heaviside firing rate function can be ill posed. More specifically, the initial-condition-to-solution map might become discontinuous in finite time. Consequently, if finite...

Authors: Bjørn Fredrik Nielsen and John Wyller

Entrainment Ranges for Chains of Forced Neural and Phase Oscillators

Sensory input to the lamprey central pattern generator (CPG) for locomotion is known to have a significant role in modulating lamprey swimming. Lamprey CPGs are known to have the ability to entrain to a bendin...

Authors: Nicole Massarelli, Geoffrey Clapp, Kathleen Hoffman and Tim Kiemel

Wave Generation in Unidirectional Chains of Idealized Neural Oscillators

We investigate the dynamics of unidirectional semi-infinite chains of type-I oscillators that are periodically forced at their root node, as an archetype of wave generation in neural networks. In previous stud...

Authors: Bastien Fernandez and Stanislav M. Mintchev

Stochastic Network Models in Neuroscience: A Festschrift for Jack Cowan. Introduction to the Special Issue

Jack Cowan’s remarkable career has spanned, and molded, the development of neuroscience as a quantitative and mathematical discipline combining deep theoretical contributions, rigorous mathematical work and gr...

Authors: Paul C. Bressloff, Bard Ermentrout, Olivier Faugeras and Peter J. Thomas

Neural Field Models with Threshold Noise

The original neural field model of Wilson and Cowan is often interpreted as the averaged behaviour of a network of switch like neural elements with a distribution of switch thresholds, giving rise to the class...

Authors: Rüdiger Thul, Stephen Coombes and Carlo R. Laing

Mathematical Frameworks for Oscillatory Network Dynamics in Neuroscience

The tools of weakly coupled phase oscillator theory have had a profound impact on the neuroscience community, providing insight into a variety of network behaviours ranging from central pattern generation to s...

Authors: Peter Ashwin, Stephen Coombes and Rachel Nicks

Wilson–Cowan Equations for Neocortical Dynamics

In 1972–1973 Wilson and Cowan introduced a mathematical model of the population dynamics of synaptically coupled excitatory and inhibitory neurons in the neocortex. The model dealt only with the mean numbers o...

Authors: Jack D. Cowan, Jeremy Neuman and Wim van Drongelen

A Mechanistic Neural Field Theory of How Anesthesia Suppresses Consciousness: Synaptic Drive Dynamics, Bifurcations, Attractors, and Partial State Equipartitioning

With the advances in biochemistry, molecular biology, and neurochemistry there has been impressive progress in understanding the molecular properties of anesthetic agents. However, there has been little focus ...

Authors: Saing Paul Hou, Wassim M. Haddad, Nader Meskin and James M. Bailey